Description
Quercetin is a plant pigment (flavonoid). It is found in many plants and foods, such as red wine, onions, green tea, apples, berries, Ginkgo biloba, St. John’s wort, American elder, and others. Buckwheat tea has a large amount of quercetin. People use quercetin as a medicine.
Quercetin is most commonly taken by mouth to treat conditions of the heart and blood vessels and prevent cancer. It is also used for arthritis, bladder infections, and diabetes. But there is limited scientific evidence to support these uses.
Coronavirus disease 2019 (COVID-19): Quercetin may have benefit for some airway infections, but there is no good evidence to support using it for COVID-19. Follow healthy lifestyle choices and proven prevention methods instead.
Effectiveness Header
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly Ineffective
- Athletic performance. Most clinical research shows that taking quercetin before exercise does not decrease fatigue or improve exercise ability.
Insufficient Evidence
- Asthma. Early research shows that taking quercetin might improve asthma symptoms and reduce the use of rescue inhalers in people with asthma.
- A blood disorder that reduces levels of protein in the blood called hemoglobin (beta-thalassemia). Some people with beta-thalassemia need blood transfusions. These transfusions can cause too much iron to build up in the body. Early research shows that taking quercetin might reduce iron levels in people with beta-thalassemia who need blood transfusions.
- Heart disease. Some research suggests that eating foods rich in quercetin, such as tea, onions and apples, may reduce the risk of death due to heart disease in elderly men. However, taking a daily quercetin supplement does not seem to improve heart disease risk factors in people who are healthy.
- Kidney damage caused by contrast dyes (contrast induced nephropathy). Early research shows that taking quercetin before and after receiving contrast dye doesn’t prevent kidney damage caused by the dye.
- Muscle damage caused by exercise. Taking quercetin doesn’t seem to help to prevent muscle soreness due to cycling or running. But it might prevent muscle damage associated with certain types of weight training.
- Airway infections caused by exercise. Early research shows that taking quercetin may reduce the chance for upper respiratory infections after heavy exercise.
- High cholesterol. Short-term use of quercetin does not appear to lower “bad cholesterol” (low-density lipoprotein (LDL) cholesterol) or total cholesterol, or to raise “good cholesterol” (high-density lipoprotein (HDL) cholesterol). But most of the studies conducted have been small and included people without high cholesterol. It’s unclear if quercetin would show benefit in only people with high cholesterol.
- High blood pressure. Early research suggests that taking quercetin produces a small decrease in blood pressure in people with untreated, mild high blood pressure. It’s unclear if this reduction in blood pressure is clinically meaningful.
- Kidney transplant. Some research suggests that taking a product containing quercetin and curcumin, starting within 24 hours of kidney transplantation, improves early function of the transplanted kidney when taken in combination with anti-rejection drugs.
- Lung cancer. Higher intake of quercetin as part of the diet has been linked with a lower risk of lung cancer in people who smoke.
- A grouping of symptoms that increase the risk of diabetes, heart disease, and stroke (metabolic syndrome). Taking quercetin doesn’t appear to improve blood sugar or insulin levels in people who are at risk for metabolic syndrome. This includes people with diabetes, obesity, polycystic ovary syndrome (PCOS), or high blood pressure. But quercetin might help lower blood sugar in people with risk factors for metabolic syndrome who are under 45 years of age, those who take quercetin for 8 or more weeks, or those taking at least 500 mg of quercetin per day. It’s unclear if quercetin helps with blood sugar in people who have already been diagnosed with metabolic syndrome.
- Swelling (inflammation) and sores inside the mouth (oral mucositis). Early research suggests that taking quercetin does not prevent mouth sores caused by cancer drugs.
- Ovarian cancer. One population study found no link between quercetin intake from the diet and the chance of ovarian cancer.
- Pancreatic cancer. Some research suggests that eating high amounts of quercetin in the diet might reduce the chance of developing pancreatic cancer, especially in men who smoke.
- A hormonal disorder that causes enlarged ovaries with cysts (polycystic ovary syndrome or PCOS). Research shows that taking quercetin improves hormone levels in women with PCOS by a small amount. In some people it might also improve how sensitive the body is to insulin. But it’s unclear if these changes lead to improvements in symptoms of PCOS such as irregular periods.
- Swelling (inflammation) of the prostate due to infection. Taking quercetin by mouth seems to reduce pain and improve quality of life, but doesn’t seem to help urination problems in men with ongoing prostate problems that aren’t due to infection.
- Rheumatoid arthritis (RA). Research shows that taking quercetin reduces pain and stiffness in women with RA. But it doesn’t seem to reduce the number of swollen or tender joints.
- Autism.
- Cataracts.
- Chronic fatigue syndrome (CFS).
- Diabetes.
- Enlarged prostate (benign prostatic hyperplasia or BPH).
- Gout.
- Hardening of the arteries (atherosclerosis).
- Hay fever.
- Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs).
- Painful urination due to swelling (inflammation) of the urethra (urethral syndrome).
- Schizophrenia.
- Stomach and intestinal ulcers.
- Viral infections.
- Other conditions.
More evidence is needed to rate quercetin for these uses.
Action
Quercetin has antioxidant and anti-inflammatory effects which might help reduce inflammation, kill cancer cells, control blood sugar, and help prevent heart disease.
Safety
When taken by mouth: Quercetin is POSSIBLY SAFE for most people when taken by mouth short-term. Quercetin has been safely used in amounts up to 500 mg twice daily for 12 weeks. It is not known if long-term use or higher doses are safe.
When taken by mouth, quercetin can cause headache and tingling of the arms and legs. Very high doses might cause kidney damage.
When given by IV: Quercetin is POSSIBLY SAFE when given intravenously (by IV) in appropriate amounts (less than 722 mg). Side effects may include flushing, sweating, nausea, vomiting, difficulty breathing, or pain at the injection site. But larger amounts given by IV are POSSIBLY UNSAFE. There have been reports of kidney damage at higher doses.
Special Precautions & Warnings:
Pregnancy and breast-feeding : There isn’t enough reliable information to know if quercetin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Kidney problems : Quercetin might make kidney problems worse. Don’t use quercetin if you have kidney problems.
Drug Interactions
Antibiotics (Quinolone antibiotics)
Interaction Rating=Moderate Be cautious with this combination.
Taking quercetin along with some antibiotics might decrease the effectiveness of some antibiotics. Some scientists think that quercetin might prevent some antibiotics from killing bacteria. But it’s too soon to know if this is a big concern.
Some of these antibiotics that might interact with quercetin include ciprofloxacin (Cipro), enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).
Cyclosporin (Neoral, Sandimmune)
Interaction Rating=Moderate Be cautious with this combination.
Cyclosporin (Neoral, Sandimmune) is changed and broken down by the liver. Quercetin might decrease how quickly the liver breaks down cyclosporin (Neoral, Sandimmune). Taking quercetin might increase the effects and side effects of this medication. Before taking quercetin talk to your healthcare provider if you take cyclosporin (Neoral, Sandimmune).
Medications changed by the liver (Cytochrome P450 2C8 (CYP2C8) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Quercetin might decrease how quickly the liver breaks down some medications. Taking quercetin along with these medications that are changed by the liver might increase the effects and side effects of your medication. Before taking quercetin talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include paclitaxel (Taxol), rosiglitazone (Avandia), amiodarone (Cordarone), docetaxel (Taxotere), repaglinide (Prandin), verapamil (Calan, Isoptin, Verelan), and others.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Quercetin might decrease how quickly the liver breaks down some medications. Taking quercetin along with these medications that are changed by the liver might increase the effects and side effects of your medication. Before taking quercetin talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Quercetin might decrease how quickly the liver breaks down some medications. Taking quercetin along with these medications that are changed by the liver might increase the effects and side effects of your medication. Before taking quercetin talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include amitriptyline (Elavil), codeine, flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), and others.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Quercetin might decrease how quickly the liver breaks down some medications. Taking quercetin along with these medications that are changed by the liver might increase the effects and side effects of your medication. Before taking quercetin talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), verapamil (Calan, Isoptin, Verelan), alfentanil (Alfenta), fentanyl (Sublimaze), losartan (Cozaar), fluoxetine (Prozac), midazolam (Versed), omeprazole (Prilosec), lansoprazole (Prevacid), ondansetron (Zofran), propranolol (Inderal), fexofenadine (Allegra), amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), sertraline (Zoloft), ketoconazole (Nizoral), itraconazole (Sporanox), and numerous others.
Medications moved by pumps in cells (P-glycoprotein Substrates))
Interaction Rating=Moderate Be cautious with this combination.
Some medications are moved by pumps in cells. Quercetin might make these pumps less active and increase how much of some medications get absorbed by the body. This might cause more side effects from some medications.
Some medications that are moved by these pumps include diltiazem (Cardizem), verapamil (Calan, Isoptin, Verelan), digoxin (Lanoxin) cyclosporine (Neoral, Sandimmune), saquinavir (Invirase), amprenavir (Agenerase), nelfinavir (Viracept), loperamide (Imodium), quinidine, paclitaxel (Taxol), vincristine, etoposide (VP16, VePesid), cimetidine (Tagamet), ranitidine (Zantac), fexofenadine (Allegra), ketoconazole (Nizoral), itraconazole (Sporanox), and others.
Herb Interactions
<div”>Herbs and supplements that might lower blood pressure: Quercetin can slightly lower blood pressure in people with high blood pressure. Taking quercetin along with other herbs and supplements that lower blood pressure might cause your blood pressure to go too low.
Other herbs and supplements that can lower blood pressure include andrographis, casein peptides, cat’s claw, coenzyme Q-10, fish oil, L-arginine, lyceum, stinging nettle, theanine, and others.
Herbs and supplements that might lower blood sugar: Quercetin might lower blood sugar in people with diabetes. Taking quercetin along with other herbs and supplements that can lower blood sugar might cause your blood sugar to go too low.
Other herbs and supplements that might lower blood sugar include agaricus mushroom, devil’s claw, fenugreek, guar gum, Panax ginseng, Siberian ginseng, and others.
Food Interactions
There are no known interactions with foods.
Dosage
The appropriate dose of quercetin depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for quercetin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Other Names
3,3′,4’5,7-Pentahydroxyflavone, Bioflavonoid, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoïde, Bioflavonoïde de Citron, Bioflavonoïdes de Citron, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoids, Citrus Bioflavonoid Extract, Citrus Flavones, Citrus Flavonoids, Complexe de Bioflavonoïde, Concentré de Bioflavonoïde, Extrait de Bioflavonoïde, Extrait de Bioflavonoïdes de Citron, Flavones de Citron, Flavonoid, Flavonoïde, Meletin, Mélétine, Quercetina, Quercétine, Sophretin, Sophrétine.
Disclaimer
Natural Medicines disclaims any responsibility related to medical consequences of using any medical product. Effort is made to ensure that the information contained in this monograph is accurate at the time it was published. Consumers and medical professionals who consult this monograph are cautioned that any medical or product related decision is the sole responsibility of the consumer and/or the health care professional. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. Except for any possible exceptions written into your License Agreement, no reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. Unlawful to download, store, or distribute content from this site.
For the latest comprehensive data on this and every other natural medicine, health professionals should consult the Professional Version of the Natural Medicines. It is fully referenced and updated daily.
© Copyright 1995-2020. Therapeutic Research Faculty, publishers of Natural Medicines, Prescriber’s Letter, and Pharmacist’s Letter. All rights reserved.
Description
Hesperidin is a plant chemical that is classified as a “bioflavonoid.” It is most commonly found in citrus fruits. People use it as medicine.
Hesperidin, alone or in combination with other citrus bioflavonoids (such as diosmin), is most commonly used for blood vessel conditions such as hemorrhoids, varicose veins, and poor circulation (venous stasis).
Effectiveness Header
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly Effective
- Poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI). Taking a particular product containing hesperidin methyl chalcone, butcher’s broom, and vitamin C by mouth seems to relieve the symptoms of poor circulation in the legs. Also, taking a different product containing hesperidin and diosmin by mouth for 2-6 months seems to improve CVI symptoms, although taking the drug Venoruton might be more effective for treating this condition.
- Hemorrhoids. Some research suggests that taking hesperidin and diosmin improves symptoms of anal hemorrhoids. It may also prevent hemorrhoids from coming back after they have healed and may help in an emergency worsening of hemorrhoids.
- Leg sores caused by weak blood circulation (venous leg ulcer). Taking a specific product containing hesperidin and diosmin by mouth for 2 months seems to improve the healing of small venous stasis ulcers when used along with compression dressings.
Possibly Ineffective
- High cholesterol. Most research shows that taking hesperidin doesn’t improve cholesterol levels.
- Obesity. Some research shows that taking glucosyl hesperidin for 12 weeks doesn’t reduce body weight in people that are slightly overweight.
Insufficient Evidence
- Athletic performance. Early research shows that taking hesperidin five hours before a workout might increase speed and energy in cyclists.
- Diabetes. Early research suggests that taking one tablet of a specific product containing hesperidin and diosmin by mouth for 45 days decreases blood sugar levels and improves blood sugar control in women with type 2 diabetes. Other research suggests that taking hesperidin each day might lower blood pressure by a small amount in people with diabetes.
- High blood pressure. Early research suggests that taking hesperidin can decrease diastolic blood pressure (the bottom number) but does not decrease systolic blood pressure (the top number) in people with or without high blood pressure. But not all research agrees.
- Swelling in the arms or legs caused by damage to the lymph system (lymphedema). Early research suggests that taking a specific product containing butcher’s broom root extract, hesperidin methyl chalcone, and vitamin C by mouth for 90 days reduces swelling in the upper arm and forearm and improves mobility and heaviness in women with swelling of the arm after breast cancer treatment. However, other research shows that taking a different product containing hesperidin and diosmin by mouth does not reduce arm swelling in women following breast cancer surgery.
- Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Early research shows that taking hesperidin might improve liver function by a small amount in adults with NAFLD.
- Rheumatoid arthritis (RA). Early research suggests that drinking a beverage containing alpha-glucosyl hesperidin for 12 weeks improves symptoms of RA.
- Varicose veins.
- Other conditions.
More evidence is needed to rate the effectiveness of hesperidin for these uses.
Action
Hesperidin may help blood vessels function better. It may also reduce inflammation.
Safety
When taken by mouth: Hesperidin is POSSIBLY SAFE for most people when taken by mouth for up to 6 months. There isn’t enough information to know if hesperidin is safe when taken for longer than 6 months. Side effects include stomach pain and upset, diarrhea, and headache.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Hesperidin is POSSIBLY SAFE for pregnant or breast-feeding women when taken by mouth with diosmin.
Bleeding disorder: Hesperidin might slow blood clotting and increase the risk of bleeding. In theory, hesperidin might make bleeding disorders worse.
Low blood pressure: Hesperidin might lower blood pressure. In theory, taking hesperidin might make blood pressure become too low in people who already have low blood pressure.
Surgery: Hesperidin might prolong bleeding. There is concern that hesperidin might increase the risk of bleeding during and after surgical procedures. Stop taking hesperidin at least 2 weeks before a scheduled surgery.
Drug Interactions
There are no known interactions with medications. Before taking this product, talk with your health professional if you take any medications.
Herb Interactions
Herbs and supplements that might lower blood pressure: Hesperidin might lower blood pressure. Using it along with other herbs and supplements that have this same effect might increase the risk of blood pressure dropping too low in some people. Some of these products include andrographis, casein peptides, cat’s claw, coenzyme Q-10, fish oil, L-arginine, lycium, stinging nettle, theanine, and others.
Herbs and supplements that might slow blood clotting: Hesperidin might slow blood clotting. Using hesperidin with other herbs that can slow blood clotting might increase the risk of bleeding in some people. These other herbs include angelica, clove, danshen, ginger, ginkgo, red clover, turmeric, vitamin E, willow, and others.
Herbs and supplements with sedative properties: Using hesperidin along with herbs that have sedative properties might increase the effects and side effects of hesperidin. Some of these supplements include 5-HTP, calamus, California poppy, catnip, hops, Jamaican dogwood, kava, St. John’s wort, skullcap, valerian, yerba mansa, and others.
Food Interactions
There are no known interactions with foods.
Dosage
The following doses have been studied in scientific research:
ADULTS
BY MOUTH:
- For poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI): A specific combination product containing hesperidin methyl chalcone 150 mg, butcher’s broom root extract 150 mg, and ascorbic acid 100 mg has been used. Also, a combination of 100-150 mg of hesperidin with 900-1350 mg of diosmin taken daily for 2-6 months has been used.
- For hemorrhoids: A combination of 150 mg of hesperidin plus 1350 mg of diosmin twice daily for 4 days, followed by 100 mg of hesperidin and 900 mg of diosmin twice daily for 3 days has been used. Also, a combination of 50 mg of hesperidin plus 450 mg of diosmin twice daily for 3 months has been used to prevent the return of hemorrhoids.
- For sores caused by weak blood circulation (venous leg ulcer): A combination of 100 mg of hesperidin and 900 mg of diosmin daily for up to 2 months has been used.
Other Names
Bioflavonoid, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoïde, Bioflavonoïde d’Agrume, Bioflavonoïdes d’Agrumes, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoids, Citrus Bioflavonoid Extract, Citrus Flavones, Citrus Flavonoids, Complexe de Bioflavonoïdes, Concentré de Bioflavonoïdes, Extrait de Bioflavonoïdes, Extrait de Bioflavonoïdes d’Agrumes, Flavonoid, Flavonoïde, Hesperidin Methyl Chalcone, Hesperidina, Hespéridine, Trimethylhesperidin-chalcon.
Disclaimer
Natural Medicines disclaims any responsibility related to medical consequences of using any medical product. Effort is made to ensure that the information contained in this monograph is accurate at the time it was published. Consumers and medical professionals who consult this monograph are cautioned that any medical or product related decision is the sole responsibility of the consumer and/or the health care professional. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. Except for any possible exceptions written into your License Agreement, no reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. Unlawful to download, store, or distribute content from this site.
For the latest comprehensive data on this and every other natural medicine, health professionals should consult the Professional Version of the Natural Medicines. It is fully referenced and updated daily.
© Copyright 1995-2020. Therapeutic Research Faculty, publishers of Natural Medicines, Prescriber’s Letter, and Pharmacist’s Letter. All rights reserved.
Description
Rutin is a plant pigment (flavonoid) that is found in certain fruits and vegetables. Rutin is used to make medicine. The major sources of rutin for medical use include buckwheat, Japanese pagoda tree, and Eucalyptus. Other sources of rutin include lime tree flowers, elder flowers, hawthorn, rue, St. John’s Wort, Ginkgo, apples, and other fruits and vegetables.
Rutin is most commonly used for swelling in the arms or legs caused by damage to the lymph system (lymphedema) and osteoarthritis. It is also used for autism, or on the skin for sun protection, but there is no good scientific evidence to support these uses.
Effectiveness Header
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly Effective
- Swelling in the arms or legs caused by damage to the lymph system (lymphedema). Some early research suggests that taking a specific product (Wobenzym N) containing rutin, pancreatin, papain, trypsin, and chymotrypsin daily for 7 weeks reduces swelling in the arm due to breast removal surgery.
- Osteoarthritis. Taking rutin by mouth in combination with trypsin and bromelain (Wobenzym PS) seems to be about as effective as the medication diclofenac (Voltaren) in relieving pain and improving knee function in people with osteoarthritis.
Insufficient Evidence
- Aging skin. Early research suggests applying a cream containing rutin to the skin twice a day reduces the size and number of wrinkles and ‘crow’s feet’ under the eyes.
- Autism. Early research suggests that taking a product containing rutin and chemicals called luteolin and quercetin might improve behavior and social functioning in children with autism.
- Airway infections caused by exercise. Early research shows that taking a product containing rutin, trypsin, and bromelain starting about one week before a marathon does not help to prevent upper airway infections after the race.
- Bleeding.
- Blood vessel disease.
- Hemorrhoids.
- Prevention of mouth ulcers associated with cancer treatments.
- Varicose veins.
More evidence is needed to rate the effectiveness of rutin for these uses.
Action
Rutin has chemicals that might have antioxidant and anti-inflammatory effects. These chemicals might offer some protection against cancer and other diseases.
Safety
When taken by mouth: Rutin is LIKELY SAFE in the amounts found in fruits and vegetables. Rutin is POSSIBLY SAFE when taken by mouth in the amounts found in medicine for up to 12 weeks. It can cause some side effects including headache, flushing, rashes, or stomach upset.
When applied to the skin: Rutin is POSSIBLY SAFE when applied to the skin as a cream.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn’t enough reliable information to know if rutin is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.
Drug Interactions
There are no known interactions with medications. Before taking this product, talk with your health professional if you take any medications.
Herb Interactions
Iron: Some information suggests that rutin might bind iron, making it less available to the body.
Food Interactions
There are no known interactions with foods.
Dosage
The following doses have been studied in scientific research:
ADULTS
BY MOUTH:
- For osteoarthritis: A combination product (Wobenzym PS), providing 600 mg of rutin, 288 mg of trypsin, and 540 mg of bromelain in divided doses has been used.
- For swelling in the arms or legs caused by damage to the lymph system (lymphedema): A specific product (Wobenzym N) containing rutin, pancreatin, papain, bromelain, trypsin, and chymotrypsin daily for 7 weeks has been used.
Other Names
Bioflavonoid, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoïde, Bioflavonoïdes d’Agrumes, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoids, Citrus Bioflavonoid Extract, Citrus Flavones, Citrus Flavonoids, Complexe de Bioflavonoïdes, Concentré de Bioflavonoïde, Eldrin, Extrait de Bioflavonoïde, Flavonoid, Flavonoïde, Flavonoïdes d’Agrumes, Quercetin-3-rhamnoglucoside, Quercetin-3-rutinoside, Quercétine-3-rutinoside, Rutina, Rutine, Rutinum, Rutosid, Rutoside, Rutosidum, Sclerutin, Sophorin.
Disclaimer
Natural Medicines disclaims any responsibility related to medical consequences of using any medical product. Effort is made to ensure that the information contained in this monograph is accurate at the time it was published. Consumers and medical professionals who consult this monograph are cautioned that any medical or product related decision is the sole responsibility of the consumer and/or the health care professional. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. Except for any possible exceptions written into your License Agreement, no reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. Unlawful to download, store, or distribute content from this site.
For the latest comprehensive data on this and every other natural medicine, health professionals should consult the Professional Version of the Natural Medicines. It is fully referenced and updated daily.
© Copyright 1995-2020. Therapeutic Research Faculty, publishers of Natural Medicines, Prescriber’s Letter, and Pharmacist’s Letter. All rights reserved.