Phytocidal

• Supports the Body’s Defenses Against Immune Challenges
• Promotes Healthy Microbial Balance and Spirochete Load
• Helps Maintain Normal Inflammatory Balance
• Provides Antioxidant Support
• Often Used in Conjunction with Cryptolepis

Phytocidal provides a blend of potent botanicals to promote healthy microbial balance and immune support for those with high spirochete load. Spirochetes are bacteria that have evolved a unique spiral shape and rotational motility that is highly effective at moving through tissue barriers. They use their unique chemotactic sensors to locate nutrients and employ toxin avoidance behaviors. Spirochetes are often spread by tick bites and accompanied by associated microbes that can make recovery especially challenging.

Andrographis paniculata Leaf Extract^†

Andrographis paniculata is a plant that has been used in Asian medicine for centuries for its broad range of health-promoting properties. Traditionally, the plant has been used as an infusion, decoction, or powder, either alone or in combination with other herbs. Recent studies have shown that, when compared to other phenolic compounds, Andrographis induced the highest activation of Nrf2, which helps reduce oxidative stress, quench free radicals, maintain endothelial health and support mitochondrial function. In another study, Andrographis demonstrated strong activity against spirochetes.

Cat’s Claw^†

Cat’s claw is an herbal medicine derived from the bark of the Uncaria tomentosa vine which is used for its inflammatory support and immune-balancing effects. It has demonstrated support for fever and fatigue by suppressing TNF-alpha synthesis and raising CD57 counts. In other studies, cat’s claw has shown strong activity against spirochetes.

Japanese Knotweed^†

Resveratrol, the most well-researched stilbene, is an antioxidant found in many plants and red wines. Studies of resveratrol have found it to enhance the potential of antioxidant and detoxification activity through Nrf2 activation. Other studies have linked resveratrol to improving blood sugar balance, maintaining normal inflammatory balance and reducing oxidative stress. In other studies, Japanese knotweed (Polygonum cuspidatum) demonstrated strong activity against spirochetes as well as other associated microbes.

Sweet Wormwood^†

Artemisia annua or sweet wormwood is a fern-like plant commonly found throughout Asia, and artemisinin is its active constituent. Artemisinin is a sesquiterpene lactone shown to have strong microbial-balancing properties. It is known to interfere with microbial metabolism by causing structural changes to unfriendly organisms that prevent them from maturing in the body. In other studies, artemisinin demonstrated potent activity against spirochetes and associated microbes.

Suggested Use:

2 capsules per day or as recommended by your health care professional.

Directions
2 capsules per day or as recommended by your health care professional.
Does Not Contain
Gluten, yeast, artificial colors and flavors.
Cautions
Do not consume this product if you are pregnant or nursing. Consult your physician for further information.

References
1. Haake, DA. Spirochetes. In: Schaechter, M, ed. Encyclopedia of Microbiology. 3rd ed. Elsevier; 2009:278-292. https://doi. org/10.1016/b978-012373944-5.00230-3.
2. Cáceres DD, Hancke JL, Burgos RA, et al. Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. Phytomedicine. 1999;6:217-223.

3. Calabrese C, Berman SH, Babish, SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res. 2000;14:333-338.

4. Verma N, Vinayak M. Antioxidant action of Andrographis paniculata on lymphoma. Mol Biol Rep. 2008;35:535-540.

5. Wong SY, Tan MG, Wong PT, et al. Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK. J neuroinflammation. 2016;13(1):251.

6. Wu KC, McDonald PR, Liu J, et al. Screening of natural compounds as activators of the keap1-nrf2 pathway. Planta medica. 2014;80(1):97.

7. Rajagopal S, Kumar RA, Deevi DS, et al. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol. 2003;3(3):147-58.

8. Mishra SK, Sangwan NS, Sangwan RS. Phcog Rev.: Plant Review Andrographis paniculata (Kalmegh): A Review. Pharmacognosy Reviews. 2007;1(2):283-98.

9. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of
Diabetes and Digestive and Kidney Diseases; 2012-. Cat’s Claw. [Updated 2019 Feb 18]. Available from: https://www.
ncbi.nlm.nih.gov/books/NBK548323/

10. Feng J, Leone J, Schweig S, Zhang Y. Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi. Front Med (Lausanne). 2020;7:6.

11. Kode A, Rajendrasozhan S, Caito S, Yang S-R, Megson IL and Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smokemediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008;294(3):L478-L488.

12. Su HC, Hung LM, Chen JK. Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. Am J Physiol
Endocrinol Metab. 2006;290(6):E1339-E1346.