CopaCalm

INGREDIENT BENEFITS

L-Theanine

L-theanine is an amino acid found abundantly in green tea. L-theanine has been shown to quickly improve stress perception and resilience. The stress-buffering mechanisms of L-theanine have been connected to its ability to increase serotonin and dopamine production in the brain.1 L-theanine has also been shown to significantly increase alpha brain wave activity, which is critical for increasing attention as well as promoting a sense of relaxation.2 In a study on healthy volunteers, electroencephalograph (EEG) readings of
participants were recorded following the ingestion of 50 mg of L-theanine. The researchers found a greater increase in alpha brain wave activity versus placebo.2 L-theanine has also been shown to have a protective effect on nerve cells overstimulated by the excitatory neurotransmitter glutamate. 3

GABA

Gamma-amino butyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. GABA provides a calming effect and is a major component of the body’s stress-fighting mechanisms. GABA has been shown in published research studies to promote a state of relaxation effects in the centralnervous system (CNS). In a double-blind study using healthy volunteers, EEG readings were obtained after 100 mg of GABA
was administered. GABA produced a highly significant increase in alpha waves, as well as a significant decrease in beta waves, when compared to the control group.4 Alpha brain waves are associated with relaxed and effortless focus, while beta waves are associated with stress, restlessness and scattered thoughts. Therefore, an increase in alpha to beta waves is associated with improved concentration and a state of centered relaxation. In a randomized, single-blind, placebo-controlled, crossoverdesigned study, among 63 adults given 100 mg of GABA versus placebo, those who took the GABA-containing capsules showed alleviation of stress induced by mental tasks.5

Huperzine Alkaloids

Huperzia serrata (whole plant extract), or Chinese club moss is a nootropic known for its potent and selective acetylcholinesterase inhibition.  Huperzine A helps to improve memory and support optimal cognitive health. A purified component derived from Chinese club moss, huperzine A has been found to support healthy cognition in a range of animal models, and phase IV clinical trials demonstrated its promotion of improved recall and cognition in elderly subjects.6 As a potent and selective acetylcholinesterase inhibitor, huperzine A helps to improve memory and support optimal cognitive health. A double-blind and matched pair study looked at 34 pairs of middle school students complaining of memory inadequacy and dividedthem into two groups by psychological health inventory (PHI), similar memory quotient and same sex and class. After four weeks, the huperzine A group (50 mcg twice a day) showed twice the improvement of the placebo group.7

Directions
2 full droppers (2 mL) two to three times per day or as recommended by your health care professional.

References

1. Yokogoshi H, Kobayashi M, Mochizuki M, Terashima T. Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. NeuroChem Res 1998; 23(5):667-73.
2. Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect of mental state. Asia Pac J Clin Nutr 2008; 17 Suppl 1:167-8.
3. Kakuda T, Hinoi E, Abe A, et al. Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain. J Neurosci Res 2008;86(8):1846-56.
4. Abdoua AM, Higashiguchi S, Horie K, et al. Relaxation and immunity enhancement effects of γ-Aminobutyric acid (GABA) administration in humans. BioFactors 2006;26: 201- 208.
5. Yoto A, Murao S, Motoki M, Yokoyama Y, Horie N, TakeshimaK, Masuda K, Kim M, Yokogoshi H. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks. Amino Acids. 2012 Sep;43(3):1331-7.
6. Wang R, Yan H, Tang XC. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin. 2006 Jan;27(1):1-26. [PMID: 16364207].
7. Sun QQ, Xu SS, Pan JL, Guo Hm, Cao WQ. Huperzine- A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Chung Kuo Yao Li Hsueh Pao. 1999 Jul;20(7):601-3.