Bergamot BPF 60C
Bergamot BPF 60C
Bergamot BPF 60C
Bergamot BPF 60C

Bergamot BPF 60C

$47.30

Bergamot BPF contains a powerful and unique array of cholesterol-balancing and cardio-protective polyphenolic flavonoids.

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With high cholesterol, you can develop fatty deposits in your blood vessels. Eventually, these deposits grow, making it difficult for enough blood to flow through your arteries. Bergamot BPF contains a powerful and unique array of cholesterol-balancing and cholesterol lowering polyphenolic flavonoids.

Emerging clinical research has demonstrated that Bergamot BPF can help maintain healthy total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and triglyceride (TRI) levels. (A1)

Can Bergamot lower cholesterol?

Research has also demonstrated that BPF provides antioxidant-balancing properties and maintains normal inflammatory balance to help preserve coronary arteries. Bergamot has traditional uses that include improving immune response and cardiovascular function. (A) There are a variety of phytochemicals that have been found in the bergamot including brutieridin and melitidin as well as other flavonoids, flavones O-glucosides and C-glucosides.
Multiple clinical trials have provided evidence that different forms of orally administered bergamot can reduce total cholesterol and low-density lipoprotein cholesterol. In vitro mechanistic studies have provided evidence that polyphenols from the bergamot can alter the function of AMPK and pancreatic cholesterol ester hydrolase (pCEH).
The use of bergamot in multiple clinical trials has consistently shown that it is well tolerated in studies ranging from 30 days to 12 weeks. This mini-review reports on the clinical studies performed with different forms of bergamot along with their effectiveness in reducing total cholesterol and LDL cholesterol in patients with hypercholesterolemia. Bergamot was observed to decrease total cholesterol from 255 to 224, LDL cholesterol from 159 to 132, and triglycerides from 159 to 133.(B)

CLINICAL APPLICATIONS

  • Promotes Healthy Cholesterol Levels
  • Multidimensional Support for Cardiovascular Health
  • Preserves Arterial Health and Elasticity
  • Supports Healthy CoQ-10 Levels

OVERVIEW

Bergamot contains high levels of flavonoids . Flavonoids are associated with many properties that can benefit a person’s health, including antioxidant and anti-inflammatory properties. In particular, bergamot contains neohesperidin and naringin, which can bind with an enzyme called HMG-CoA reductase. This enzyme is involved in the production of cholesterol. Binding to it can interrupt cholesterol production and may reduce cholesterol levels. This process is similar to the function of statins, a medication that aims to lower LDL.

Additionally, a 2022 paper notes that bergamot extract can effectively lower cholesterol levels when combined with artichoke leaf extract. Researchers found that not only was this combination effective, it also resulted in lower cholesterol levels for people who did not respond to bergamot extract on its own.

Optimizing cardiovascular health is a leading concern for many adults, and maintaining balanced cholesterol levels are an important part of that process. Though cholesterol can be consumed through food, circulating cholesterol levels are primarily produced and controlled by the liver using the rate control enzyme, HMG-CoA reductase (HMGCR). Because of its pronounced role in cholesterol synthesis, inhibiting HMGCR has become a primary target of many traditional therapies.

Numerous clinical trials have shown the specific BPF found in Bergamot BPF works at the level of the liver to help maintain and support healthy cholesterol levels and preserve coronary arteries by maintaining normal inflammatory balance.

What are Bergamot Polyphenolic Fractions?

Bergamot (Citrus bergamia) is a citrus plant that grows almost exclusively in the narrow coastal Calabria region in southern Italy. The local population quickly discovered bergamot juice could be used to help support healthy cholesterol levels and optimize cardiovascular wellness.

 

Bergamot’s health benefits derive from its unique profile of phenolic compounds such as, neoeriocitrin, neohesperidin, naringin, rutin, neodesmin, rhoifolin and poncirin. Naringin has been shown to be beneficial in maintaining normal inflammatory balance, while neoeriocitrin and rutin have been found to exhibit a strong capacity to quench free radicals and maintain healthy LDL cholesterol levels. Also, bergamot is rich in brutieridine and melitidine, which have a unique ability to dampen HMG-CoA reductase.

Using a patented extraction technology through collaborative works of various universities and research institutions, Bergamot BPF contains Bergamonte®, BPF/Bergamot Polyphenolic Fraction (by H&AD), the highest concentration available of these potent phenolic compounds. Clinical trials quoted were conducted on BPF.

Cholesterol-Balancing Properties†

In a placebo-controlled, clinical trial consisting of 77 patients divided into four treatment groups, 1,000 mg of BPF helped maintain healthy levels of all blood lipid markers (HDL, LDL, TC, TRI).1 Also, this same clinical trial showed that BPF activated the inflammatory-balancing enzyme AKT and reduced malondialdehyde production in neutrophils.1

Another clinical trial conducted on 80 patients over six months showed 1,500 mg of BPF maintained normal levels of small density LDL and supported normal carotid IMT thickness.2 In a placebocontrolled study involving 238 patients, 1,000 mg of BPF maintained healthy cholesterol levels and outperformed the group receiving the traditional therapy.3

Following a 60-day wash out phase in patients who had been on traditional therapies, 1,500 mg of BPF maintained normal LDL levels and optimized several other parameters of cardiovascular health.3 Several other recently published placebo-controlled clinical trials have also documented that BPF can help maintain normal inflammatory balance, antioxidant potential, healthy cholesterol levels, and CoQ-10 levels in humans.4-12

Bergamot

Directions

2 capsules per day or as recommended by your health careprofessional.

Does Not Contain

Gluten, corn, yeast, artificial colors and flavors.

Cautions

If you are pregnant or nursing, consult your health care professional before taking this product.

References

  1. Gliozzi M, Walker R, Muscoli S, Vitale C, Gratteri S, Carresi C, Musolino V, Russo V, Janda E and Ragusa S. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. International journal of cardiology. 2013;170:140-145.
  2. Toth PP, Patti AM, Nikolic D, Giglio RV, Castellino G, Biancucci T, Geraci F, David S, Montalto G and Rizvi A. Bergamot Reduces Plasma Lipids, Atherogenic Small Dense LDL, and Subclinical Atherosclerosis in Subjects with Moderate Hypercholesterolemia: A 6 Months Prospective Study. Frontiers in pharmacology. 2015;6.
  3. Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C, Visalli V, Muscoli S, Ragusa S and Muscoli C. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. Fitoterapia. 2011;82:309-316.
  4. Di Donna L, Iacopetta D, Cappello AR, Gallucci G, Martello E, Fiorillo M, Dolce V and Sindona G. Hypocholesterolaemic activity of 3-hydroxy-3-methyl-glutaryl flavanones enriched fraction from bergamot fruit (Citrus bergamia):“In vivo” studies. Journal of Functional Foods. 2014;7:558-568.
  5. Campolongo G, Riccioni CV, Raparelli V, Spoletini I, Marazzi G, Vitale C and Volterrani M. The combination of nutraceutical and simvastatin enhances the effect of simvastatin alone in normalising lipid profile without side effects in patients with ischemic heart disease. IJC Metabolic & Endocrine. 2016;11:3-6
  6. Cappello A, Dolce V, Iacopetta D, Martello M, Fiorillo M, Curcio R, Muto L and Dhanyalayam D. Bergamot (Citrus bergamia Risso) Flavonoids and Their Potential Benefits in Human Hyperlipidemia and Atherosclerosis: an Overview. Mini reviews in medicinal chemistry. 2015.
  7. Giglio RV, Patti AM, Nikolic D, Volti GL, Al-Rasadi K, Katsiki N, Mikhailidis DP, Montalto G, Ivanova E and Orekhov AN. The effect of bergamot on dyslipidemia. Phytomedicine. 2015.
  8. Janda E, Lascala A, Martino C, Ragusa S, Nucera S, Walker R, Gratteri S and Mollace V. Molecular mechanisms of lipidand glucose-lowering activities of bergamot flavonoids. PharmaNutrition. 2016.
  9. Mollace V, Ragusa S, Sacco I, Muscoli C, Sculco F, Visalli V, Palma E, Muscoli S, Mondello L and Dugo P. The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation. Journal of cardiovascular pharmacology and therapeutics. 2008;13:120-129.
  10. Risitano R, Currò M, Cirmi S, Ferlazzo N, Campiglia P, Caccamo D, Ientile R and Navarra M. Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes. PLoS One. 2014;9:e107431.
  11. Trombetta D, Cimino F, Cristani M, Mandalari G, Saija A, Ginestra G, Speciale A, Chirafisi J, Bisignano G and Waldron K. In vitro protective effects of two extracts from bergamot peels on human endothelial cells exposed to tumor necrosis factor-α (TNF-α). Journal of agricultural and food chemistry. 2010;58:8430-8436.
  12. Benson J. ALTERNATIVE MEDICINE CABINET: Bergamot. Alternative Medicine. 2015:49.

*Research quoted are based on BPF by H&AD

Supplement Facts

Supplement Facts
Serving Size 2 Capsules
Servings Per Container 30 & 60
Amount Per
2 capsules contain Serving
Bergamot Orange Extract
(Citrus bergamia Risso)(Fruit) (Bergamonte®) (38% Bergamot
Polyphenolic Fraction® comprised of Neohesperidin,
Naringin, Neoeriocitrin, Brutieridin, and Melitidin)
1 g
V3
*
* Daily Value not established
% Daily
Value

Brand

Ortho Molecular Products

Brand