Acetyl-Glutathione is a novel oral acetyl-glutathione formulation that is stable in the stomach and gastrointestinal tract, well absorbed, and able to enter the cells directly and present to the cytosol for mitochondrial entry.* Acetyl-Glutathione uses pure Emothion® glutathione as the starting material.**Also see a review article on glutathione by Michael Ash, BSc, DO, ND, F.DipION, and Marty Jones, PharmD that discusses acetylated oral glutathione.
Glutathione is a substance made from the amino acids glycine, cysteine, and glutamic acid. It is produced naturally by the liver and involved in many processes in the body, including tissue building and repair, making chemicals and proteins needed in the body, and for the immune system.
People take glutathione by mouth for treating cataracts and glaucoma, preventing aging, treating or preventing alcoholism, asthma, cancer, heart disease (atherosclerosis and high cholesterol), hepatitis, liver disease, diseases that weaken the body’s defense system (including AIDS and chronic fatigue syndrome), memory loss, Alzheimer’s disease, osteoarthritis, and Parkinson’s disease. Glutathione is also used for maintaining the body’s defense system (immune system) and fighting metal and drug poisoning.
Glutathione is breathed in (inhaled) for treating lung diseases, including idiopathic pulmonary fibrosis, cystic fibrosis, and lung disease in people with HIV disease.
Healthcare providers give glutathione as a shot (by injection into the muscle) for preventing poisonous side effects of cancer treatment (chemotherapy) and for treating the inability to father a child (male infertility).
Healthcare providers also give glutathione intravenously (by injection into the vein, by IV) for preventing “tired blood” (anemia) in kidney patients undergoing hemodialysis treatment, preventing kidney problems after heart bypass surgery, treating Parkinson’s disease, improving blood flow and decreasing clotting in individuals with “hardening of the arteries” (atherosclerosis), treating diabetes, and preventing toxic side effects of chemotherapy.
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
- Chemotherapy side effects. Administering glutathione intravenously (by IV) seems to help prevent chemotherapy side effects.
- Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Early research shows that taking glutathione by mouth for 4 months might reduce blood levels of a marker of liver damage called ALT and triglyceride levels in people with liver disease not related to alcohol. However, glutathione does not appear to improve liver stiffness in people with this disease.
- Parkinson disease. Early research shows that taking glutathione as a nasal spray three times daily for 3 months does not appear to improve symptoms of Parkinson disease.
- A group of eye disorders that can lead to vision loss (glaucoma).
- Alcohol use disorder.
- Alzheimer disease.
- Athletic performance.
- Chronic fatigue syndrome (CFS).
- Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility).
- Cystic fibrosis.
- Decline in memory and thinking skills that occurs normally with age.
- Hardening of the arteries (atherosclerosis).
- Heart disease.
- High cholesterol.
- Lung diseases.
- Skin lightening.
- Swelling (inflammation) of the liver (hepatitis).
- Other conditions.
More evidence is needed to rate glutathione for these uses.
Glutathione is involved in many processes in the body, including tissue building and repair, making chemicals and proteins needed in the body, and for the immune system.
Glutathione is POSSIBLY SAFE when taken by mouth, by inhalation, or by injection into the muscle or into the veins. There isn’t a lot of information available about the possible side effects of glutathione. It might cause rash when applied to the skin, or irritability in children when taken by mouth or applied to the skin.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking glutathione if you are pregnant or breast feeding. Stay on the safe side and avoid use.
Asthma: Do not inhale glutathione if you have asthma. It can increase some asthma symptoms.
There are no known interactions with medications. Before taking this product, talk with your health professional if you take any medications.
There are no known interactions with herbs and supplements.
There are no known interactions with foods.
The following doses have been studied in scientific research:
BY INJECTION INTO THE VEIN OR MUSCLE:
- For chemotherapy side effects: Doses of 1.5 to 3 grams/m² of glutathione have been given in a 15-20 minute time period right before chemotherapy treatments. Also, 1.5 grams/m² of glutathione has been given over 15 minutes prior to chemotherapy plus 600 mg of glutathione injected into the muscle on days 2 to 5.
Gamma-Glutamylcysteinylglycine, Gamma-L-Glutamyl-L-Cysteinylglycine, Gamma-L-Glutamyl-L-Cystéinylglycine, Glutathion, Glutatión, L-Gamma-Glutamyl-L-Cysteinyl-Glycine, L-Gamma-Glutamyl-L-Cystéinyl-Glycine, L-Glutathion, L-Glutathione, GSH, N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine.
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